Location (Coahoma County): US 61/MS 6 between Clarksdale and Lyon to US 49/61 north of Lyon
Mileage in Coahoma County:  About 1.5 miles

Location (DeSoto County): US 61 south of Walls to US 61 north of Walls
Mileage in DeSoto County:  About 3 miles

Total Distance: Officially, 4.789 miles of MS 161 exist in Mississippi.

Multiplexes: None

NHS: None

Freeway Segments: None

Other Multilane Segments:  None

Interchanges: None

Notes:
MS 161 is the designation used by MDOT for those sections of the old US 61 roadbed that the state still wants to maintain. There are two such sections in Mississippi currently.

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